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    1. Neuroscience

    Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

    Hannah L Payne, Ranran L French ... Jennifer L Raymond
    Patterned optogenetic stimulation and analysis of neural activity provide convergent evidence that cerebellar Purkinje cells drive eye movements with a rapid rate code, without an additional contribution of spike irregularity.
    1. Neuroscience

    Inhibitory control of correlated intrinsic variability in cortical networks

    Carsen Stringer, Marius Pachitariu ... Nicholas A Lesica
    A new cortical network model fit directly to multi-neuron recordings reveals that local inhibitory feedback can control neural dynamics, modulate brain state and enhance sensory processing.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Neuroscience

    Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

    Lawrence Huang, Peter Ledochowitsch ... Lu Li
    Simultaneous calcium imaging and cell-attached recording in GCaMP6 transgenic mice in vivo reveals spiking-fluorescence relationship that supports more refined inference of neuronal activities from calcium imaging data.
    1. Neuroscience

    Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice

    Sean E Cavanagh, Joni D Wallis ... Laurence T Hunt
    Variability in individual neurons' temporal receptive fields of integration is found to explain the heterogeneity of neuronal responses observed in prefrontal cortex during reward-guided decision making.
    1. Neuroscience

    Neural variability determines coding strategies for natural self-motion in macaque monkeys

    Isabelle Mackrous, Jérome Carriot ... Maurice J Chacron
    Whether central vestibular neurons implement faithful stimulus encoding for the vestibulo-occular reflex or optimized coding via temporal whitening for other vestibular functions is determined by neural variability.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak, Kara L Marshall ... Ellen A Lumpkin
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Neuroscience

    Altered basal ganglia output during self-restraint

    Bon-Mi Gu, Joshua D Berke
    Rats are slower to initiate actions when these actions may need to be cancelled, and this slowing is associated with increased and more variable neural firing in the substantia nigra pars reticulata.
    1. Neuroscience

    Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

    Antimo Buonocore, Xiaoguang Tian ... Ziad M Hafed
    Sensory activity within the superior colliculus is read out by downstream motor structures and contributes to individual saccade kinematics with single spike precision.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet, Mark J Roberts ... Peter De Weerd
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.