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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

    Owen Leddy, Forest M White, Bryan D Bryson
    Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.
    1. Physics of Living Systems

    Optical mapping of ground reaction force dynamics in freely behaving Drosophila melanogaster larvae

    Jonathan H Booth, Andrew T Meek ... Malte C Gather
    A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.
    1. Neuroscience

    Competition between parallel sensorimotor learning systems

    Scott T Albert, Jihoon Jang ... Reza Shadmehr
    When a common error drives parallel implicit and explicit learning systems, increases in the explicit response will suppress implicit adaptation.
    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Neuroscience

    Amygdala-ventral striatum circuit activation decreases long-term fear

    Susana S Correia, Anna G McGrath ... Ki A Goosens
    Behavior- or optogenetic-driven activation of a basolateral amygdala projection to the nucleus accumbens enhances infralimbic cortex activity and long-term fear extinction.
    1. Neuroscience

    The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

    Lydia Gruber, Rafael Cantera ... Jürgen Rybak
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan M Shugarts Devanapally, Aishwarya Sathya ... Antony M Jose
    Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.
    1. Neuroscience

    A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

    Kylie S Chew, Jordan M Renna ... Samer Hattar
    A single subpopulation of photoreceptors constitutes a shared node in the neural networks that regulate light-dependent maturation of the circadian clock and light-independent refinement of retinal ganglion cell projections to the brain.
    1. Ecology
    2. Computational and Systems Biology

    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    Iva Veseli, Yiqun T Chen ... A Murat Eren
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu, François GC Blot ... Martijn Schonewille
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.