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    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide, Kristina Lukacova ... Annemie Van der Linden
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

    Fu-Qing Jiang, Kun Liu ... Xu-Feng Qi
    Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m6A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
    1. Cell Biology
    2. Immunology and Inflammation

    Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

    Daniel Blumenthal, Vidhi Chandra ... Janis K Burkhardt
    The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen, Ines Winkler ... Titia K Sixma
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.
    1. Neuroscience

    Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

    Kate Nussenbaum, Catherine A Hartley
    The use of prior experience to adaptively prioritize information in memory increases from childhood to adulthood and engages corticostriatal circuitry.
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

    Ava C Carter, Jin Xu ... Howard Y Chang
    A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski, Michael A Welsh ... E Hesper Rego
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes

    Yi Feng, Rafik Neme ... Laura F Landweber
    The comparison of three ciliate species that share complex pathways for natural genome editing allows capture of intermediate states in the acquisition of scrambled genes and elucidating a pathway for the origin and evolution of extremely rearranged chromosomes.
    1. Microbiology and Infectious Disease

    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

    Ashley M Ngo, Matthew J Shurtleff ... Andreas S Puschnik
    The ER membrane protein complex (EMC) facilitates the correct topology of the flavivirus non-structural proteins NS4A and NS4B at the ER membrane critical for viral replication.