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The differential conformational space accessible to the two domains of TRBP, even though they both adopt a canonical dsRBD fold, affect how they interact with target RNAs.

Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.

Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.

Molecular simulations, small-angle X-ray and neutron scattering experiments and previously measured NMR experiments were combined to study the structure and dynamics of the proteins and lipids in a nanodisc.

Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.

Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.

The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.

I-Spin enables researchers to decode motor unit firings from surface and intramuscular electromyographic signals in real time.

A novel model of the human mesiotemporal lobe suggests that its broad roles in cognition can be explained by how its cytoarchitecture and form relate to large-scale functional motifs.

Product release from human lysozyme is mediated by an intermediate state with transient weak interactions between the product and enzyme.