814 results found
    1. Neuroscience

    The recovery of standing and locomotion after spinal cord injury does not require task-specific training

    Jonathan Harnie et al.
    Restoring locomotion after complete spinal cord injury does not require locomotor training, only the return of sufficient excitability within neurons of the spinal cord.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Computational and Systems Biology
    2. Neuroscience

    Integrated systems analysis reveals conserved gene networks underlying response to spinal cord injury

    Jordan W Squair et al.
    Integrating decades of small-scale experiments with human gene expression data provides a systems-level view of the coordinated molecular processes triggered by spinal cord injury, and their relationship to recovery.
    1. Neuroscience

    Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

    Ying Wang et al.
    Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.
    1. Neuroscience

    Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

    Patrick D Ganzer et al.
    Precisely-timed bursts of closed-loop vagus nerve stimulation during rehabilitation restore neural connectivity and substantially improve recovery of motor function after SCI.
    1. Neuroscience

    Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

    Vanessa Plantier et al.
    Calpain is a promising therapeutic target to reduce spasticity after a spinal cord injury.
    1. Stem Cells and Regenerative Medicine

    Neuroepithelial Stem Cells: The many roles of C1q

    Mark Noble, Christoph Pröschel
    The ability of C1q to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
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    1. Neuroscience

    Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice

    Carmelo Bellardita et al.
    Spinal excitatory interneurons trigger persistent neural activity in spinal network to generate muscle spasms after spinal cord injury.
    1. Neuroscience

    Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

    Anitha Manohar et al.
    After complete spinal transection in adult rats, careful combinations of pharmacological and physical therapies create a novel cortical sensorimotor circuit that may bypass the lesion through biomechanical coupling, allowing animals to recover unassisted hindlimb locomotion.
    1. Neuroscience

    Spinal Cord Injury: Is the vagus nerve our neural connectome?

    V Reggie Edgerton, Parag Gad
    What are the implications of the vagus nerve being able to mediate the time-dependent plasticity of an array of sensorimotor networks?.
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