In the Drosophila central brain, synaptic connectivity extracts visual-spatial information from the axons of looming sensitive LC6 neurons that terminate in a glomerulus with minimal retinotopy.
A new tool to visualize blood-feeding mosquitoes in high resolution and quantitatively characterize their behavior sheds light on contact-dependent sensing and blood-feeding dynamics of several medically relevant mosquito species.
Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.
Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
Integrating gene expression with genetic association data provided insights into the functional relevance of genetic risk for a complex disease, thus implicating folliculin as a putative diabetic retinopathy susceptibility gene.
