An unbiased transcriptional profiling screen reveals the secreted matrix metalloproteinase MMP-1 is a transcriptional target of the ensheathing glial receptor Draper following acute axon injury in adult Drosophila.
Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
Xinyi Jenny He, Janki Patel ... Matthew R Banghart
Mu and delta opioid receptors signal independently in hippocampal parvalbumin interneurons to regulate somato-dendritic excitability and synaptic transmission, with the delta opioid receptor dominating the response to enkephalin.
Stephan Raiders, Erik Calvin Black ... Aakanksha Singhvi
A peripheral sense-organ glia actively engulfs fragments of a sensory neuron ending to modify neuron shape and associated animal sensory behavior in Caenorhabditis elegans..
Competition between adhesive and tensile forces regulates axon fasciculation, thus introducing a new role of mechanical tension in the development of neural networks.
Fabrizio Orsenigo, Lei Liu Conze ... Elisabetta Dejana
Single-cell RNA analysis of brain endothelium identifies the angiogenic venous capillary subset and respective resident endothelial progenitors at the origin of CCM lesions, while arterial endothelial cells are unaffected.
Population cortical recordings and computational network modeling support a novel mechanism underlying spontaneous UP-DOWN dynamics consisting on non-rhythmic transitions between a silent attractor and a low-rate inhibition-stabilized attractor.
