209 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

    Ivana Primorac et al.
    The spindle assembly protein Bub3 recruits the checkpoint kinase Bub1 to kinetochores by binding to phosphorylated MELT repeats in the kinetochore subunit Knl1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

    Katharina Overlack et al.
    The mechanism behind the recruitment of the spindle assembly checkpoint protein BubR1 to the kinetochore illustrates how gene duplication and sub-functionalization can influence the functional complexity of a protein network.
    1. Cell Biology

    Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

    Margarida Moura et al.
    Inactivation of the master mitotic checkpoint regulator Mps1 by protein phosphatase 1 is required for timely segregation of the genetic material during cell division.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer et al.
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

    Qiaozhen Ye et al.
    TRIP13 inactivates the spindle assembly checkpoint by converting MAD2 from its active ‘closed’ state to its inactive ‘open’ state.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mitosis: Checkpoint proteins come under scrutiny

    Maria Mora-Santos, Jonathan BA Millar
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    1. Cell Biology

    Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

    Anna P Baron et al.
    Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
    1. Cell Biology

    Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

    Marco Novais-Cruz et al.
    Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.
    1. Cell Biology

    The equatorial position of the metaphase plate ensures symmetric cell divisions

    Chia Huei Tan et al.
    Human cells center the position of the metaphase plate before anaphase onset to ensure the formation of equal-sized daughter cells.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

    Robbyn L Weaver et al.
    Strengthening of spindle assembly checkpoint activity and attachment error correction through BubR1 manipulation preserves genomic integrity and protects against tumor formation.

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