239 results found
    1. Developmental Biology
    2. Medicine

    VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

    Derek C Sung, Xiaowen Chen ... Mark L Kahn
    VE-cadherin is required for trophoblast invasion of the maternal decidua and spiral arteries.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

    Sima Stroganov, Talia Harris ... Michal Neeman
    Expression of Bisphosphoglycerate mutase, a key enzyme affecting the release of oxygen from hemoglobin, is augmented in the murine placenta challenged by gestational hypoxia in mice while its expression is attenuated in placenta of human FGR.
    1. Cell Biology
    2. Developmental Biology

    Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

    Katherine Young Bezold Lamm, Maddison L Johnson ... Louis J Muglia
    Loss of Inverted Formin-2 impairs intracellular trafficking and trophoblast invasion, resulting in maternal hypertension and intrauterine growth restriction, which represents a novel model of impaired placental invasion that encompasses critical aspects of the great obstetrical syndromes.
    1. Neuroscience

    A spiral attractor network drives rhythmic locomotion

    Angela M Bruno, William N Frost, Mark D Humphries
    The neural population of the Aplysia's pedal ganglion are a low-dimensional spiral attractor, and the parameters of the attractor directly define the properties of the Aplysia's escape locomotion behaviour.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll, Tatsuro Nishikino ... Jun Liu
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Neuroscience

    Intrinsic mechanical sensitivity of mammalian auditory neurons as a contributor to sound-driven neural activity

    Maria C Perez-Flores, Eric Verschooten ... Ebenezer N Yamoah
    In vitro and in vivo physiological analyses reveal that mammalian auditory neuron intrinsic mechanical sensitivity contributes to sound-evoked activity and explains other previously unexplained auditory neuron features.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The role of scaffold reshaping and disassembly in dynamin driven membrane fission

    Martina Pannuzzo, Zachary A McDargh, Markus Deserno
    Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.
    1. Developmental Biology
    2. Plant Biology

    A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis

    Yassin Refahi, Géraldine Brunoud ... Christophe Godin
    A stochastic model of phyllotaxis can explain the striking irregularities observed in the spiral patterns of plants and predicts that perturbation patterns provide key information about the underlying biochemical mechanisms.
    1. Neuroscience

    Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

    Guoqiang Wan, Maria E Gómez-Casati ... Gabriel Corfas
    Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.
    1. Neuroscience

    Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

    Weijian Yang, Luis Carrillo-Reid ... Rafael Yuste
    An all-optical 3D two-photon imaging and photostimulation platform was demonstrated, with the capability to precisely stimulate a large group of cells in mice cortex in vivo with low laser power.

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