494 results found
    1. Neuroscience

    Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons

    Elise LV Malavasi et al.
    Dynamic early clusters of nodal proteins in peripheral nerves represent a neurofascin-dependent developmental stage of node assembly during myelination that precedes heminode formation.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil et al.
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Injection with Toxoplasma gondii protein affects neuron health and survival

    Oscar A Mendez et al.
    Multi-level profiling of Toxoplasma gondii-injected neurons identifies brain regions and neuron subtype predilections as well as the effect of Toxoplasma interactions on neuron physiology and health.
    1. Neuroscience

    Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia

    Alexis Bédécarrats et al.
    An atypical neuronal pacemaker mechanism triggers feeding motor pattern in Aplysia..
    1. Neuroscience

    Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

    Line S Löken et al.
    Although primary sensory neuron-derived calcitonin gene-related peptide (CGRP) contributes to the processing of pain messages, an understudied population of dorsal horn CGRP-expressing interneurons also contributes to the processing of mechanical sensitivity.
    1. Cell Biology
    2. Neuroscience

    The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

    Katalin Skrapits et al.
    Neuroanatomical studies reveal presence and cholinergic phenotype of 150,000-200,000 extrahypothalamic gonadotropin-releasing hormone neurons in human basal ganglia and basal forebrain, and RNA-sequencing detects gonadotropin-releasing hormone receptor-1 expression in cholinergic interneurons but not in spiny projection neurons of the human putamen.
    1. Neuroscience

    The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

    Emily G Berghoff et al.
    Circuit transcription factors may define the differentiation and assembly of distinct neurons into functional circuitry.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Developmental Biology
    2. Neuroscience

    Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons

    Eljo Van Battum et al.
    3D imaging and time-lapse video-microscopy show that the PlexinB2 receptor controls the tempo of granule cell differentiation and sets the pace of their migration in mouse cerebellum.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson et al.
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.

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