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Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine
Zhiling Li et al.
Calcium response profiling of large populations of enteric neurons reveals hard-wired neural circuits that reflect the motility program portfolio of the intestinal region they occupy.
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
Travis A Babola et al.
Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
Revisiting the role of Dcc in visual system development with a novel eye clearing method
Robin J Vigouroux et al.
A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit,
Yi Bessie Liu et al.
A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons
Caitlin Engelhard et al.
A protein called Megf8 regulates the activity of key signaling molecules involved in the development of the peripheral nervous system.
Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit
Maggie M Shin et al.
Genetic and anatomical analyses of Hox gene function uncover a limb-independent program of sensory neuron fate specification and connectivity.
mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
Linqing Miao et al.
The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.
Reconstruction of genetically identified neurons imaged by serial-section electron microscopy
Maximilian Joesch et al.
A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
Guoqiang Wan et al.
Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.
Generalization of learned responses in the mormyrid electrosensory lobe
Conor Dempsey et al.
In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.
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