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    1. Cell Biology
    2. Neuroscience

    Pericytes control vascular stability and auditory spiral ganglion neuron survival

    Yunpei Zhang, Lingling Neng ... Xiaorui Shi
    Pericytes in the adult ear are critical for vascular stability and spiral ganglion neuron health.
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
    1. Neuroscience

    GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology

    Mark A Rutherford, Atri Bhattacharyya ... Maria Eulalia Rubio
    Ultrastructural and imaging studies of cochlear ribbon synapses demonstrate cis- and trans-synaptic molecular and structural effects in the absence of the AMPA-type glutamate receptor subunit GluA3 during mouse development in ambient sound levels.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

    Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves
    Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
    1. Neuroscience

    Neural signatures of auditory hypersensitivity following acoustic trauma

    Matthew McGill, Ariel E Hight ... Daniel B Polley
    Chronic two-photon calcium imaging, optogenetics, and operant behavioral approaches were leveraged to show that hyperactivity, hyperresponsivity, and hypersynchronization in auditory cortex neural ensembles can account for auditory hypersensitivity following acoustic trauma.
    1. Neuroscience

    Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

    Haiwei Zhang, Hongchen Li ... Ping Lv
    In the cochlea, repressor element 1-silencing transcription factor (REST) regulates the expression levels of Kv7.4 and alterations of REST functions result in progressive hearing loss.
    1. Neuroscience

    Magnetic stimulation allows focal activation of the mouse cochlea

    Jae-Ik Lee, Richard Seist ... Shelley Fried
    Coil-based CIs have the potential to enhance the quality of restored hearing for people with severe to profound hearing loss.
    1. Neuroscience

    Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

    Amy Richardson, Victoria Ciampani ... Ian D Forsythe
    The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
    1. Neuroscience

    Intrinsic mechanical sensitivity of mammalian auditory neurons as a contributor to sound-driven neural activity

    Maria C Perez-Flores, Eric Verschooten ... Ebenezer N Yamoah
    In vitro and in vivo physiological analyses reveal that mammalian auditory neuron intrinsic mechanical sensitivity contributes to sound-evoked activity and explains other previously unexplained auditory neuron features.
    1. Developmental Biology

    The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice

    Alena Maul, Antje Kathrin Huebner ... Christian A Hübner
    Ano1 deletion disrupts Ca2+ waves within Kölliker’s organ, reduces burst-firing activity and frequency selectivity of auditory brainstem neurons in the medial nucleus of the trapezoid body, and impairs the functional refinement of its projections to the lateral superior olive.