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Analysis of Cabp1/2 double knockout phyenotype and rescue by viral delivery of Cabp2 identifies the interplay between two CaBPs to promote sustained synaptic transmission at the inner hair cell synapses.

Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.

The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.

Ano1 deletion disrupts Ca²⁺ waves within Kölliker’s organ, reduces burst-firing activity and frequency selectivity of auditory brainstem neurons in the medial nucleus of the trapezoid body, and impairs the functional refinement of its projections to the lateral superior olive.

Ultrastructural and imaging studies of cochlear ribbon synapses demonstrate cis- and trans-synaptic molecular and structural effects in the absence of the AMPA-type glutamate receptor subunit GluA3 during mouse development in ambient sound levels.

Coil-based CIs have the potential to enhance the quality of restored hearing for people with severe to profound hearing loss.

The auditory hair cell synaptic ribbon maintains vesicle pools near release sites in order to support sustained and timed vesicle release.

What happened when eLife decided to eliminate accept/reject decisions after peer review?

Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.

Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.