56 results found
    1. Neuroscience

    Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

    Charles-Francois V Latchoumane, Joon-Hyuk Lee ... Hee-Sup Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

    Ewa K Bomba-Warczak, Karen M Velez ... Francesca E Duncan
    Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    The role of heterochronic gene expression and regulatory architecture in early developmental divergence

    Nathan D Harry, Christina Zakas
    Changes in the amount and timing of gene expression during early development contribute to evolutionary divergence and life-history changes, even within a species.
    1. Evolutionary Biology

    Early evolution of the ecdysozoan body plan

    Deng Wang, Yaqin Qiang ... Jian Han
    Discovery of new taxon of Saccorhytida suggests that the ground pattern of Ecdysozoa may not be elongated vermiform instead sac-like in shape.
    1. Ecology
    2. Evolutionary Biology

    The trunk replaces the longer mandible as the main feeding organ in elephant evolution

    Chunxiao Li, Tao Deng ... Shiqi Wang
    The long mandibles were gradually replaced by more flexible trunks in the evolution of proboscideans.
    1. Immunology and Inflammation

    G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

    Yi-Hong Li, Yi-Sen Yang ... Liquan Huang
    Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
    1. Developmental Biology

    FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility

    Zhiming Li, Xingping Liu ... Shuiqiao Yuan
    Animal models and molecular data reveal how FBXO24 regulates mRNA expression and MIWI degradation in the round spermatids.
    1. Neuroscience

    Interactions between circuit architecture and plasticity in a closed-loop cerebellar system

    Hannah L Payne, Jennifer L Raymond, Mark S Goldman
    A comprehensive modeling approach reconciles experimental observations with classic plasticity mechanisms in the cerebellar cortex, demonstrating how learning-related changes in neural activity can appear to contradict the sign of the underlying plasticity when feedback is present.
    1. Physics of Living Systems

    Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host–microbe associations

    Janna C Nawroth, Christoph Giez ... Thomas CG Bosch
    Spontaneous contractions allow shedding of the fluid boundary layer and thereby stabilize microbiota.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

    Josep Martí-Solans, Aina Børve ... Timothy Lynagh
    Expression patterns and biophysical properties of acid-sensing ion channels in numerous bilaterian animals offer insight into the deployment of ion channels by the evolving nervous system in complex animals.

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