56 results found
    1. Neuroscience

    Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

    Charles-Francois V Latchoumane, Joon-Hyuk Lee ... Hee-Sup Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay, Marko Popović ... Suzanne Eaton
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao, Alvina G Lai ... Aziz Aboobaker
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

    Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
    A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    The induction of pyrenoid synthesis by hyperoxia and its implications for the natural diversity of photosynthetic responses in Chlamydomonas

    Peter Neofotis, Joshua Temple ... David M Kramer
    The algal pyrenoid is formed at high O2 levels, even when CO2 is high, implying that a product of photosynthesis, most likely H2O2 acts as a signal.
    1. Physics of Living Systems

    Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host–microbe associations

    Janna C Nawroth, Christoph Giez ... Thomas CG Bosch
    Spontaneous contractions allow shedding of the fluid boundary layer and thereby stabilize microbiota.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The role of scaffold reshaping and disassembly in dynamin driven membrane fission

    Martina Pannuzzo, Zachary A McDargh, Markus Deserno
    Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li, Carrie Barton ... Matthew P Harris
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

    Aftab Nadeem, Alexandra Berg ... Sun Nyunt Wai
    MakA, a pore-forming cytotoxin produced by Vibrio cholerae, forms oligomers and remodels membranes into high-curvature tubes, resulting in membrane integrity loss inside acidified organelle lumens or when cultured with cells in an acidic medium.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans

    Alice Easton, Shenghan Gao ... Thomas B Nutman
    Comparative phylogenomic analyses based on a new reference-quality human Ascaris genome assembly reveals a pig/human interbred species complex with implications for Ascaris control worldwide.

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