244 results found
    1. Evolutionary Biology

    Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

    Jan Attig et al.
    During evolutionary progression of Alu-exons, repressive U-tracts buffer sudden gains in 3' splice site strength and prevent inclusion of cryptic exons.
    1. Neuroscience

    Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

    Pengcheng Zhou et al.
    A new open-source computational toolbox for processing in vivo microendoscopic calcium imaging data performs signal demixing and denoising much more accurately than previously available methods, significantly improving the utility of this imaging modality.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi et al.
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Neuroscience

    Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons

    Daniel J Galtieri et al.
    Pedunculopontine neurons can evoke burst spiking in substantia nigra dopaminergic neurons without engaging a subtype of glutamate receptor previously thought to be necessary for this spiking mode.
    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li et al.
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Cell Biology
    2. Neuroscience

    Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

    Matthew S Scarnati et al.
    Local presynaptic protein synthesis occurring at established nerve terminals in the mammalian brain provides a mechanism for rapidly controlling or restoring presynaptic proteins that affect neurotransmitter release and presynaptic efficiency.

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