Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.
Diverse and widespread novel alternative pre-mRNA splicing isoforms as well as cycling alternative splicing events that undergo time-of-day dependent changes are identified in isolated Drosophila neuron groups.
Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.