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    1. Neuroscience

    Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

    Ella Podvalny et al.
    Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.
    1. Neuroscience

    Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

    Shuang Li et al.
    Mice that successfully avoid developing tinnitus despite exposure to excessive noise show spontaneous recovery of KCNQ2/3 potassium channel activity associated with a reduction in HCN channel activity in auditory brainstem neurons.
    1. Neuroscience

    Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period

    Qiang Qiu et al.
    A delicate balance of neural activity is required during critical period in establishing innate odor preference.
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Developmental Biology

    Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes

    Qiping Dong et al.
    Increased spontaneous calcium activity in Rett syndrome astrocytes is a key cell-autonomous phenotype that affects synaptic function and network activity.
    1. Cell Biology
    2. Computational and Systems Biology

    EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

    Martin Baumdick et al.
    Plasticity arising from autocatalytic receptor activation coexists with robustness in ligand responsiveness only by differential endosomal sorting of spontaneous and ligand-activated EGFR as distinct molecular states.
    1. Neuroscience

    Asymmetric effects of activating and inactivating cortical interneurons

    Elizabeth AK Phillips, Andrea R Hasenstaub
    The consequences of manipulating neuronal activity with techniques such as optogenetics are highly sensitive to methodological details, highlighting the need for caution when interpreting results.
    1. Neuroscience

    Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

    Austin L Reese, Ege T Kavalali
    Individual neurons can adjust the strength of their synapses by using spontaneous calcium influx through NMDA receptors to trigger the release of additional calcium from intracellular stores, which can in turn be used to regulate protein synthesis.
    1. Neuroscience

    Differential dopaminergic modulation of spontaneous cortico–subthalamic activity in Parkinson’s disease

    Abhinav Sharma et al.
    Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
    1. Cell Biology
    2. Neuroscience

    Dendritic mitochondria reach stable positions during circuit development

    Michelle C Faits et al.
    Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.