In the fly, Drosophila melanogaster, the population activity of descending neurons (DNs) projecting from the brain to the motor system is predominantly correlated with locomotion with only a few DNs encoding grooming or olfactory signals in the absence of behavior.

Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.

Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.

Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.

An innovative, fully computerized approach for measuring spontaneous social behavior in mice closely follows murine ethology, eliminates crucial sources of data irreproducibility and enables fast, inexpensive assessment of sociability in group-housed subjects.

Complex, multi-scale natural behaviors may arise from subpopulations of neurons in cerebral cortex operating near the tipping point of a phase transition, that is, near criticality.

A combination of electrophysiological and optogenetic approaches revealed a causal role for glutamatergic neurons in the prelimbic cortex in regulating individual differences in decision-making strategies during a threat-avoidance vs. reward-approach conflict paradigm in rats.

Major neuron classes are activated when the fly walks, whether it chooses or is forced to do so.

Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB₂ receptor agonist that are mediated through CB₂ receptors of neurons and lymphocytes.

Procedures were developed to perform mesoscale 2-photon Ca²⁺ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.