6,141 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

    Daniel Coutandin et al.
    p63 uses an intricate network of domain-domain interactions to control its function in long-term quality maintenance of resting oocytes.
    1. Chromosomes and Gene Expression

    PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

    Shuchi Agrawal Singh et al.
    A key transcription-factor for osteogenic differentiation, PLZF, acts as a transcriptional activator by binding to active developmental enhancers and facilitates mediator recruitment, but is not involved in enhancer looping.
    1. Neuroscience

    During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost

    Noam Almog et al.
    Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

    Florian Hinte et al.
    A herpesvirus harnesses the unfolded protein response to regulate its own life cycle, revealing an unexpected role of XBP1u as a potent repressor of the most important viral promoter.
    1. Neuroscience

    Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice

    Carmelo Bellardita et al.
    Spinal excitatory interneurons trigger persistent neural activity in spinal network to generate muscle spasms after spinal cord injury.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    p53 Family Proteins: Damage limitation

    Ivano Amelio, Gerry Melino
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    1. Neuroscience

    Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control

    Rebecca A Callahan et al.
    Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.
    1. Neuroscience

    Optogenetic dissection of descending behavioral control in Drosophila

    Jessica Cande et al.
    Optogenetically activated individual descending neurons in Drosophila melanogaster drive varied stereotyped motor patterns that are often influenced by the animal's initial behavioral state.
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis et al.
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al.
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.

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