152 results found
    1. Structural Biology and Molecular Biophysics

    CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits

    Louise Meigh, Sophie A Greenhalgh ... Nicholas Dale
    A CO2 receptor and a mechanism for the CO2-mediated opening of gap junction hemichannels have been identified.
    1. Cell Biology
    2. Cancer Biology

    Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

    Alexandra Naba, Karl R Clauser ... Richard O Hynes
    Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
    1. Neuroscience

    CA1 cell activity sequences emerge after reorganization of network correlation structure during associative learning

    Mehrab N Modi, Ashesh K Dhawale, Upinder S Bhalla
    As mice learn to associate events separated in time, neurons within the CA1 region of the hippocampus progressively reorganize their firing patterns, leading to a relay of cellular activity that bridges the two events.
    1. Cell Biology
    2. Plant Biology

    Abscisic acid dynamics in roots detected with genetically encoded FRET sensors

    Alexander M Jones, Jonas ÅH Danielson ... Wolf B Frommer
    Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

    Hoong Chuin Lim, Ivan Vladimirovich Surovtsev ... Christine Jacobs-Wagner
    In vitro, in vivo and in silico evidence suggests that bacteria exploit intrinsic chromosomal fluctuations to achieve intracellular transport.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone, Coralie Fumeaux ... Patrick H Viollier
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Cell Biology

    Controlling fertilization and cAMP signaling in sperm by optogenetics

    Vera Jansen, Luis Alvarez ... Dagmar Wachten
    Optogenetics is a non-invasive way to study cAMP signaling in sperm cells, which is able to control sperm motility and fertilization.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3

    Christine Mieck, Maxim I Molodtsov ... Stefan Westermann
    The kinesin-14 motor Kar3 moves along microtubules using a previously undescribed mechanism that critically requires the presence of a non-catalytic head.
    1. Ecology
    2. Microbiology and Infectious Disease

    Mapping microbial ecosystems and spoilage-gene flow in breweries highlights patterns of contamination and resistance

    Nicholas A Bokulich, Jordyn Bergsveinson ... David A Mills
    Mapping microbial landscapes in indoor environments can predict how contaminants and spoilage resistance genes propagate within food-production environments, yielding novel insight for controlling spoilage.
    1. Chromosomes and Gene Expression

    The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

    Eric Wang, Shinpei Kawaoka ... Christopher R Vakoc
    TRIM33 performs an essential function in B cell acute lymphoblastic leukemia through an association with a single cis element.

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