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Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.

MakA, a pore-forming cytotoxin produced by Vibrio cholerae, forms oligomers and remodels membranes into high-curvature tubes, resulting in membrane integrity loss inside acidified organelle lumens or when cultured with cells in an acidic medium.

Combined experimental and theoretical analysis identifies a molecular mechanism akin to working memory that enables single cells to perform complex navigation tasks in changing growth factor fields, beyond simple stimulus-response associations.

The self-organising condensin MukBEF positions chromosomal origins in Escherichia coli..

Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.

Investigations of the reaction center (RC)-light harvesting (LH) complex from an ancient chlorosome-less anoxygenic phototroph Roseiflexus castenholzii reveal the structural basis by which carotenoids assembly regulates the architecture and quinone exchange of bacterial RC-LH complex.

Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.

Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.