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Sweet and umami taste receptors are capable of sensing chloride ions, a component of table salt other than the salty taste-inducing component, sodium ions, and induce preferable taste sensations such as sweet taste.

Increased stiffness of sensory neurons in the absence of microtubule acetylation renders mice profoundly insensitive to touch and pain.

TRIM33 performs an essential function in B cell acute lymphoblastic leukemia through an association with a single cis element.

The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.

Notch1 activates autophagy to regulate the survival of T-regulatory cells from mice.

The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.

CBFs, the central regulators of low-temperature signaling, have a function to directly activate the expression of COOLAIR, an antisense RNA of FLC, during vernalization process, but COOLAIR is not required for the vernalization response.

The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.

Electrophysiology measurements characterized eight optogenetic methods, including a new reporter mouse expressing soma-localized light-activated chloride channels, for inactivating small regions of mouse neocortex.

Biochemical and genetic characterization of the Cdc6 replication initiator reveals similarities in the helicase loading reaction between bacteria and eukaryotes.