545 results found
    1. Biochemistry and Chemical Biology

    Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function

    Jason C Bell et al.
    Individual SSB-ssDNA complexes undergo reversible condensation and de-condensation that is modulated by RecOR during recombination.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

    Io Yamamoto et al.
    The discovery of non-canonical telomeric dsDNA-binding proteins in Caenorhabditis elegans reveal their contribution in the maintenance of telomere length and germline immortality.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

    Chun Zhou et al.
    X-ray crystallography reveals that the Dna2 nuclease-helicase contains a long tunnel through which single-stranded DNA threads, and an allosteric mechanism for displacing the DNA-binding protein Rpa that restricts cleavage to the proper polarity.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al.
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer et al.
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Structural Biology and Molecular Biophysics

    Structural basis for DNA 5´-end resection by RecJ

    Kaiying Cheng et al.
    A structural investigation reveals details of the mechanism by which the nuclease RecJ processes DNA ends to repair double strand breaks.
    1. Chromosomes and Gene Expression

    Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

    Winnie Tan et al.
    Biochemical reconstitution experiments uncover the ubiquitin-mediated function of a DNA repair protein, key to the understanding of Fanconi Anemia, a cancer-associated bone marrow failure syndrome.
    1. Structural Biology and Molecular Biophysics

    Human RPA activates BLM’s bidirectional DNA unwinding from a nick

    Zhenheng Qin et al.
    hRPA permits the BLM helicase to bidirectionally unwind DNA from a nick which could potentially facilitate its function switching in DNA repair and promote end resection in homologous recombination.
    1. Structural Biology and Molecular Biophysics

    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans

    Jihee Hwang et al.
    RecO efficiently displaces SSB from ssDNA without consuming ATPs using its two DNA-binding sites, even though SSB binds to ssDNA approximately 300 times more strongly than RecO does.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

    Janine Weber et al.
    The crystal structure of Pur-alpha in complex with DNA reveals its molecular mechanisms of nucleic-acid binding and unwinding, allowing for a better understanding of its essential role in neurons.

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