5 results found
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim, Lea Adolf ... Simon Heilbronner
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Microbiology and Infectious Disease

    Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus

    Lea Antje Adolf, Angelika Müller-Jochim ... Simon Heilbronner
    Staphylococcal heme acquisition needs a highly structured cell envelope, the membrane transporter accumulates in membrane domains most likely to allow concerted passage of heme from the cell wall-funnel to the membrane.
    1. Microbiology and Infectious Disease

    Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

    Janine Bowring, Maan M Neamah ... José R Penadés
    Structural and genetic analyses reveal the highly evolved and unprecedented biological strategy used by SaPIs to spread in nature.
    1. Microbiology and Infectious Disease

    Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

    Alan M O'Neill, Kate A Worthing ... Richard L Gallo
    The discovery and development of a feline skin commensal bacterium for bacteriotherapy against skin disease, that could benefit patients due to established low cytotoxicity, broad-spectrum antimicrobial activity and anti-inflammatory activity.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malodour precursor transport in the human axilla

    Gurdeep S Minhas, Daniel Bawdon ... Simon Newstead
    Discovery of the structural basis for recognition and uptake of a human precursor for body odour production reveals an important role for bacterial peptide transport and novel routes to prevent its production in humans.

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