4,632 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: Of starch and spit

    Mareike C Janiak
    Animals living alongside humans have multiple copies of the gene for alpha-amylase, the enzyme that breaks down starchy foods, and high levels of this protein in their saliva.
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    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Recreating the synthesis of starch granules in yeast

    Barbara Pfister et al.
    Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.
    1. Cell Biology

    A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

    Alberto T Gatta et al.
    A new family of sterol-specific lipid transfer proteins has been found that anchors in the endoplasmic reticulum; some of these proteins stretch across membrane contacts and mediate sterol traffic from the plasma membrane.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.
    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek et al.
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

    Ignacio Izeddin et al.
    While the transcription factor c-Myc explores the space in the nucleus in an unrestricted manner, the elongation factor P-TEFb's sampling of the nucleus is constrained to a complex domain with fractal characteristics.
    1. Neuroscience

    Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae

    Daeyeon Kim et al.
    In naturalistic conditions, larvae of the Drosophila group exhibit species-specific strategies to search for food resources through a primitive form of risk-taking behavior that is controlled by a tradeoff between exploitation and odor-driven exploration.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The mechanism of variability in transcription start site selection

    Libing Yu et al.
    Variability in bacterial transcription start site selection involves DNA “scrunching” and “anti-scrunching,” which may represent a general mechanism for start site selection in all organisms.
    1. Developmental Biology

    Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

    Jingyue Xu et al.
    SHH signaling acts through FOXF1/2 transcription factors and antagonizes BMP signaling to specify oral fate and pattern the oral-aboral axis of the mandibular arch to ensure proper formation of jaws.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

    Li Li et al.
    Live imaging captures dynamics of Huntingtin aggregates plaguing the genome and waylaying target search.

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