587 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

    Yongjie Wei et al.
    Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

    Bin Z He et al.
    The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
    1. Biochemistry and Chemical Biology

    daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

    Jonathan D Hibshman et al.
    daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni et al.
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.
    1. Cell Biology

    AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

    Arnold Y Seo et al.
    Upon AMPK activation by acute glucose restriction, Atg14p shifts its distribution from ER exit sites to liquid-ordered membrane domains on the vacuolar surface where, together with Atg6p, it facilitates LD-specific autophagy (i.e., microautophagy of lipid droplets) for energy production and long-term survival of starved cells.
    1. Cell Biology

    In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

    Angelica Aguilera-Gomez et al.
    Amino-acid induced Sec body formation is mediated by PARP16 dependent MARylation of Sec16, a component of the endoplasmic reticulum exit site.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A glucose-starvation response regulates the diffusion of macromolecules

    Ryan P Joyner et al.
    During stress conditions, eukaryotic cells dramatically alter their biophysical properties to regulate diffusion of macromolecules.
    1. Neuroscience

    AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

    Moloud Ahmadi, Richard Roy
    AMP-activated protein kinase directly coordinates glutamatergic signalling during starvation in C. elegans.
    1. Cell Biology
    2. Genetics and Genomics

    The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

    Heather P Harding et al.
    Genetic lesions that compromise the ribosome P-stalk implicate direct signalling from the ribosome to the translation initiation factor eIF2 kinase GCN2 in the cellular response to amino acid starvation.

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