3,549 results found
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Neuroscience

    Arguments for the biological and predictive relevance of the proportional recovery rule

    Jeff Goldsmith, Tomoko Kitago ... John W Krakauer
    The proportional recovery rule, an apparently simple model that nonetheless requires careful statistical treatment, remains an important biological and predictive framework for stroke recovery.
    1. Neuroscience

    Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

    Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
    Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.
    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu, Raymond J Dolan ... Timothy E Behrens
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Medicine

    Research: Adequate statistical power in clinical trials is associated with the combination of a male first author and a female last author

    Willem M Otte, Joeri K Tijdink ... Christiaan H Vinkers
    An analysis of 31,873 clinical trials shows that adequate statistical power was most often present in trials with a male first author and a female last author.
    1. Neuroscience

    Decomposing the role of alpha oscillations during brain maturation

    Marius Tröndle, Tzvetan Popov ... Nicolas Langer
    Applying decomposition of oscillatory and aperiodic signal components to developmental EEG data provides a solution for the problems in the investigation of alpha power during brain maturation.
    1. Neuroscience

    Amphetamine reduces reward encoding and stabilizes neural dynamics in rat anterior cingulate cortex

    Saeedeh Hashemnia, David R Euston, Aaron J Gruber
    Amphetamine reduces reward signaling by neurons in rat prefrontal cortex, but increases the stability of population dynamics, which account for animals’ increased task engagement, despite reduced reward motivation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

    D Herbert Opi, Olivia Swann ... J Alexandra Rowe
    Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay, Sahar I El Shair ... Murray J Cairns
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.

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