12,246 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantitative analysis of tumour spheroid structure

    Alexander P Browning, Jesse A Sharp ... Matthew Simpson
    A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.
    1. Epidemiology and Global Health

    Science Forum: Unit of analysis issues in laboratory-based research

    Nick R Parsons, M Dawn Teare, Alice J Sitch
    A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.
  1. Scientific Publishing: Transparent reporting of research results in eLife

    M Dawn Teare
    Manuscripts should include all the experimental and statistical details that are needed to replicate the experiments and analyses reported in them.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
  2. Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca, Elizabeth MA Hensor ... M Dawn Teare
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.
    1. Neuroscience

    Bayesian inference of population prevalence

    Robin AA Ince, Angus T Paton ... Philippe G Schyns
    Bayesian estimation of the proportion of the population that would show an effect in an experiment provides a broadly applicable alternative to standard null hypothesis tests on the population mean with several advantages.
    1. Neuroscience
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    Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

    Tamar R Makin, Jean-Jacques Orban de Xivry
    What can authors and reviewers do to keep common statistical mistakes out of the literature?
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana, Simona Cocco, Rémi Monasson
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips, Katherine R Lawrence ... Michael M Desai
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.
    1. Neuroscience

    Neuropsychological evidence of multi-domain network hubs in the human thalamus

    Kai Hwang, James M Shine ... Aaron Boes
    Lesions to the anterior-medio-dorsal thalamus cause widespread behavioral impairments across multiple cognitive domains, suggesting that thalamic hubs are critical for interconnecting diverse cognitive processes.

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