3,388 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu et al.
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone et al.
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin et al.
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Inference and control of the nosocomial transmission of methicillin-resistant Staphylococcus aureus

    Sen Pei et al.
    The asymptomatic colonization and importation of methicillin-resistant Staphylococcus aureus (MRSA) in hospital settings can be inferred from observed cases using combined model-inference methods and used to inform improved interventions.
    1. Epidemiology and Global Health

    Early analysis of the Australian COVID-19 epidemic

    David J Price et al.
    An analysis of Australian case data demonstrates how the combined strategy of border measures, case targeted interventions, and social distancing effectively contained the first epidemic wave of COVID-19.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

    Benson Ogunjimi et al.
    An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

    Stephan Wilmes et al.
    IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
    1. Computational and Systems Biology
    2. Neuroscience

    Statistical context dictates the relationship between feedback-related EEG signals and learning

    Matthew R Nassar et al.
    The P300, an electroencephalography (EEG) component known to be evoked by surprising events, predicts learning in a bidirectional manner that depends critically on the surrounding statistical context.
    1. Cancer Biology

    Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

    Mee Rie Sheen et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.

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