2,923 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone et al.
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin et al.
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Inference and control of the nosocomial transmission of methicillin-resistant Staphylococcus aureus

    Sen Pei et al.
    The asymptomatic colonization and importation of methicillin-resistant Staphylococcus aureus (MRSA) in hospital settings can be inferred from observed cases using combined model-inference methods and used to inform improved interventions.
    1. Epidemiology and Global Health

    Early analysis of the Australian COVID-19 epidemic

    David J Price et al.
    An analysis of Australian case data demonstrates how the combined strategy of border measures, case targeted interventions, and social distancing effectively contained the first epidemic wave of COVID-19.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

    Benson Ogunjimi et al.
    An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.
    1. Computational and Systems Biology
    2. Neuroscience

    Statistical context dictates the relationship between feedback-related EEG signals and learning

    Matthew R Nassar et al.
    The P300, an electroencephalography (EEG) component known to be evoked by surprising events, predicts learning in a bidirectional manner that depends critically on the surrounding statistical context.
    1. Neuroscience

    Detecting changes in dynamic and complex acoustic environments

    Yves Boubenec et al.
    Psychophysics experiments and EEG recordings reveal that people's performance in detecting unexpected changes in complex auditory scenes can be modeled as a process of sensory evidence accumulation.
    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Cancer Biology

    Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

    Mee Rie Sheen et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.

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