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    1. Neuroscience

    Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

    Gabriel E Romero, Laurence O Trussell
    In a fast brainstem relay controlling hearing sensitivity, descending synaptic control from midbrain provides the dominant source of excitation, due to a distinct form of synaptic plasticity.
    1. Neuroscience

    An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa V Goodrich
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

    Amy Richardson, Victoria Ciampani ... Ian D Forsythe
    The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
    1. Cell Biology
    2. Developmental Biology

    Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

    Fabrice Bouilloux, Jérôme Thireau ... Frédéric Marmigère
    The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Neuroscience

    Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion

    Adriane G Otopalik, Marie L Goeritz ... Eve Marder
    Reliable neuronal physiology can arise from variable and inefficient morphologies.
    1. Neuroscience

    A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

    David Goyer, Marina A Silveira ... Michael T Roberts
    VIP neurons are a novel class of inferior colliculus stellate neurons that project to long-range auditory and non-auditory targets and integrate inputs from the auditory brainstem and contralateral IC.
    1. Neuroscience

    Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

    Jan H Kirchner, Lucas Euler ... Julijana Gjorgjieva
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Selective recruitment of the cerebellum evidenced by task-dependent gating of inputs

    Ladan Shahshahani, Maedbh King ... Jörn Diedrichsen
    The human cerebellum shows fMRI activity for many tasks – however, the inputs from the neocortex are upregulated in a task-dependent manner when cerebellar computation is required.
    1. Neuroscience

    Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

    Ting Zhang, Ling Zhu ... Mark C Gillies
    The important role of serine biosynthesis in Müller cells may explain why the macula is so much more prone to developing disease than the rest of the retina.