Stem cell transplantation reduces intraocular pressure and preserves retinal ganglion cell function in a mouse glaucoma model, which could lead to a novel therapy for glaucoma to preserve vision.

Single cell RNA sequencing leads to identification and separation of transcriptionally and functionally heterogeneous, natural human satellite cells, including a subpopulation marked by CAV1 harboring quiescence phenotypes and engraftment potential.

Application of a polyvinyl alcohol-based culture system reveals extensive differentiation but simultaneous robust murine hematopoietic stem cell (HSC) expansion, which are characterized by phenotypic, functional, and molecular properties shared with freshly isolated bone marrow HSCs.

Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.

Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.

The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.

Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.

Building on previous work (Dye et al., 2015) showing that pluripotent stem cell derived lung organoids were immature/fetal, the current study shows that in vivo transplantation leads to mature tissue, reminiscent of adult airways.

Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.

Using a lineage tracing model, it is demonstrated that adult murine hematopoiesis is contingent on the continuous output from HSCs, with quantitative contributions that are dependent on lineage-type and age.