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    1. Neuroscience
    2. Physics of Living Systems

    Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

    Mélanie Tobin, Atitheb Chaiyasitdhi ... Pascal Martin
    The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.
    1. Cancer Biology
    2. Cell Biology

    DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

    Samantha VH Bayer, Whitney R Grither ... Gregory D Longmore
    The action of the collagen receptor DDR2 in CAFs regulates Rap1-Talin1 mediated Integrin mechanotransduction in breast tumors to impact tumor stiffness and metastases.
    1. Cell Biology
    2. Developmental Biology

    Organ sculpting by patterned extracellular matrix stiffness

    Justin Crest, Alba Diz-Muñoz ... David Bilder
    Direct measurement of finely patterned mechanical properties in a native basement membrane demonstrate how force asymmetries arising from this extracellular matrix, rather than from cells, can precisely sculpt a tissue.
    1. Medicine

    Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

    Stefan Möstl, Fabian Hoffmann ... Jens Jordan
    Novel blood pressure devices provide an estimated pulse wave velocity, which is no substitute for measured pulse wave velocity and clinicians should be aware that it only reflects trends derived from representative population samples based on age and blood pressure.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda, Javier Vaquero ... Emmanuel Donnadieu
    Tumor stiffness blocks T cell migration in tumors.
    1. Cell Biology
    2. Neuroscience

    Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery

    Ting-Ya Chang, Chen Chen ... Pei-Lin Cheng
    Hippocampal neurons undergo bi-stable behavior as neurites emerge, and the dominance of either state is determined by environmental mechanical properties and paxillin-associated cellular endocytic activities.
    1. Cell Biology
    2. Developmental Biology

    Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

    Su-Jin Heo, Tristan P Driscoll ... Robert L Mauck
    Nuclear reorganization and stiffening accompanies mesenchymal stem cell differentiation, resulting in increased sensitivity to mechanical perturbation.
    1. Cell Biology
    2. Immunology and Inflammation

    Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

    Daniel Blumenthal, Vidhi Chandra ... Janis K Burkhardt
    The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.
    1. Microbiology and Infectious Disease

    Biofilms deform soft surfaces and disrupt epithelia

    Alice Cont, Tamara Rossy ... Alexandre Persat
    The growth of multicellular bacterial structures called biofilms generates forces that deform soft material substrates and disrupt epithelial cell layers, potentially mechanically damaging host tissue.
    1. Physics of Living Systems

    Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

    Carly M Krull, Haiyi Li, Amit Pathak
    Nuclear export inhibition reveals concurrent epithelial and mesenchymal phenotypes that cause mechanosensitive disorder in collectively migrating epithelia.