318 results found
    1. Epidemiology and Global Health

    Estimating effectiveness of case-area targeted response interventions against cholera in Haiti

    Edwige Michel et al.
    Case-area targeted interventions conducted by rapid response teams appeared significantly effective to mitigate and shorten local cholera outbreaks in the Centre department of Haiti in 2015-2017.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang et al.
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Quantitative analysis of 1300-nm three-photon calcium imaging in the mouse brain

    Tianyu Wang et al.
    Quantitative experiments and analysis determine the limit of excitation power of 1300-nm three-photon microscopy, and the imaging depth where three-photon outperforms two-photon for calcium imaging in the mouse brain.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

    Sebastià Franch-Expósito et al.
    CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.
    1. Neuroscience

    Invariant representations of mass in the human brain

    Sarah Schwettmann et al.
    A network of brain regions implicated in physical inference represents abstract, generalizable variables used as inputs to physics engines.
    1. Neuroscience

    Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

    Paul Pfeiffer et al.
    Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within a cluster of channels allow for a memory of previous electrical activity for several seconds.
    1. Stem Cells and Regenerative Medicine

    Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters

    Aliaksandr Khaminets et al.
    Cohesin-regulated 3D genome conformation controls activity of transcription factor Escargot in intestinal stem cells, prevents premature differentiation into enterocytes and maintains intestinal homeostasis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Length-dependent disassembly maintains four different flagellar lengths in Giardia

    Shane G McInally et al.
    Giardia, a multi-ciliated parasitic protist, maintains four different flagellar lengths by balancing flagellar length-independent IFT-mediated assembly with length-dependent kinesin-13 mediated disassembly.
    1. Structural Biology and Molecular Biophysics

    HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

    Michael Morse et al.
    APOBEC3G, an anti-viral protein with the capability to inhibit HiV-1 infectivity, binds single stranded DNA in multiple physical conformations, enabling complex interactions that allow APOBEC3G to perform multiple diverse functions.

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