2,175 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe et al.
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Amol K Bhandage et al.
    Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.
    1. Neuroscience

    The SSVEP tracks attention, not consciousness, during perceptual filling-in

    Matthew J Davidson et al.
    The strength of frequency-tagged neural activity during perceptual filling anti-correlates with the contents of consciousness, yet positively correlates with a neural measure of attention, dissociating these often confounded brain processes.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

    Damien Lemoine et al.
    A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
    1. Structural Biology and Molecular Biophysics

    A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

    Priscilla S-W Yeung et al.
    Electrophysiological and molecular modeling studies identify a sulfur-aromatic interaction between the hydrophobic channel gate and a nearby methionine residue, termed the "gate latch", which is essential for Orai1 pore opening.
    1. Immunology and Inflammation

    LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

    Jack P Green et al.
    Depletion of LRRC8A provides genetic evidence for the importance of Cl- channels in NLRP3 activation.
    1. Neuroscience

    The amygdala instructs insular feedback for affective learning

    Dominic Kargl et al.
    Hierarchical information flow in a cortico-limbic loop between the insular cortex, central amygdala and the cholinergic basal forebrain links bodily states with environmental stimuli to guide fear and reward behavior.
    1. Neuroscience

    A new no-report paradigm reveals that face cells encode both consciously perceived and suppressed stimuli

    Janis Karan Hesse, Doris Y Tsao
    Conscious visual percepts are encoded by face patches in the absence of report, can be decoded from population recordings, and are multiplexed with the veridical physical stimulus.
    1. Computational and Systems Biology
    2. Neuroscience

    Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

    Jonathan Oesterle et al.
    Bayesian simulator-based inference is used to infer the parameters of complex multicompartment models of retinal neurons from two-photon imaging data.

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