Neurons differ in their impact on collective cortical activity, with sensitive neurons forming a stable topological core, implicated in cortical-state transitions, while peripheral insensitive neurons are more responsive to stimuli.
Systematic stimulation across the entire visual field reveals that zebrafish optokinetic behavior is most strongly driven by lateral stimulus locations, as a result of both retinal and extra-retinal effects.
Parvalbumin-containing inhibitory neurons are crucial for expression of plasticity in adult visual cortex that supports visual recognition memory, but not for expression of ocular dominance plasticity that results from monocular deprivation.
Goal-directed interaction with objects and spatial navigation are subserved by the perirhinal-lateral entorhinal networks and the postrhinal-medial entorhinal networks, respectively, with action-based functional differentiation more strongly represented in the entorhinal cortex than its upstream.
Networks simulations and in vivo imaging suggest a stable backbone of stimulus representation formed by neurons with low population coupling, alongside a flexible substrate of neurons with high population coupling.