359 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Peter L Freddolino et al.
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Single-cell analysis of transcription kinetics across the cell cycle

    Samuel O Skinner et al.
    By properly accounting for gene copy number and cell-cycle effects, single cell snapshots of nascent and mature mRNA can be used to unveil the stochastic kinetics of gene activity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

    Guillermo Rodrigo, Mario A Fares
    Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A continuum model of transcriptional bursting

    Adam M Corrigan et al.
    Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
    1. Developmental Biology and Stem Cells

    Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies

    Silvia Urbansky et al.
    Functional recapitulation of a likely evolutionary gain in gene expression shows that two genes are sufficient to switch mesoderm cell internalization from stochastic cell ingression to coordinated epithelial invagination.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer et al.
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Plant Biology

    Plant Biology: When the time is ripe

    Siobhan M Brady
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    1. Microbiology and Infectious Disease

    Host Defense: Are we immune by chance?

    Andrea L Graham, Ann T Tate
    The sooner the immune system launches, the greater the chances the host has of survival.
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