435 results found
    1. Plant Biology

    Plant Biology: When the time is ripe

    Siobhan M Brady
    Version of Record
    Insight
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster, Mirko Messa ... Timothy A Ryan
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Stem Cells and Regenerative Medicine

    Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

    Vitor H Teixeira, Parthiban Nadarajan ... Sam M Janes
    Cell replenishment within the airways is governed by the random division of a population of basal progenitor cells, in a process that is accelerated in smokers.
    1. Neuroscience

    Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

    Keming Zhou, Tamara M Stawicki ... Yishi Jin
    The precise position of UNC-13 at the active zone near a synapse depends on the N-terminus of the protein, and the C2A domain in particular, and is essential for accelerating neurotransmitter release.
    1. Structural Biology and Molecular Biophysics

    Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel

    Yong Wang, Yanxin Liu ... Paul R Selvin
    Observation by single molecule FRET of MscL, a prokaryotic mechanosensitive channel, reveals that MscL opens via the helix-tilt model and its pore reaches 2.8 nm in diameter.
    1. Neuroscience

    Sensory experience during locomotion promotes recovery of function in adult visual cortex

    Megumi Kaneko, Michael P Stryker
    Mice that viewed a visual stimulus whilst running showed recovery of the neuronal responses that had been lost due to early visual deprivation, with potential relevance for amblyopia.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

    Sakari Vanharanta, Christina B Marney ... Joan Massagué
    Inactivation of a multifunctional RNA-binding protein can lead to the acquisition of pro-metastatic phenotypes, possibly by stabilizing large-scale transcriptomic changes that provide a selective advantage during cancer progression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera, Bibhusita Pani ... Evgeny Nudler
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

    Brenda Y Han, Shuang Wu ... Jason G Cyster
    A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.

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