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Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.

A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.

Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.

Telomere length distributions can be used to infer important properties of stem cell proliferation.

Human colonic organoid monolayers self organize into regularly spaced stem and differentiated cell compartments, which are maintained by waves of ERK activity originating from extruded/dying cells.

In neurodegeneration of Gaucher disease, glucosylceramides trigger neuroinflammation via attrition of homeostatic microglia and transition to lipid-laden damage-associated microglia concurrently with infiltration of diverse immune cells including activated NK cells and CCR2⁺ macrophages, ameliorated by substrate reduction therapy.

A parametrization-invariant synaptic plasticity rule based on natural-gradient descent leads to multiple predictions for the biological plasticity process, some of which relate to well-studied phenomena such as heterosynaptic plasticity.

Mitochondrial flashes counteract the imbalance of ATP supply-and-demand and constitute an auto-regulator of ATP homeostasis in the heart.

The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.

Spatiotemporal manipulations of insomniac reveal that this gene regulates the birth and development of sleep-regulatory neurons, enabling their proper function in adulthood.