634 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone et al.
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Computational and Systems Biology
    2. Neuroscience

    Multivariate stochastic volatility modeling of neural data

    Tung D Phan et al.
    Multivariate stochastic volatility models provide insights into understanding the dynamics and connectivity of neural signals during cognitive tasks.
    1. Developmental Biology

    Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

    Ritika Giri et al.
    How gene expression noise is regulated is critical for cell fate and tissue patterning.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A continuum model of transcriptional bursting

    Adam M Corrigan et al.
    Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
    1. Neuroscience

    Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

    Janus RL Kobbersmed et al.
    Heterogeneous distances between vesicles and Ca2+-channels make synapses prone to short-term depression, however, Ca2+-dependent increases in the number of release-ready vesicles supports facilitation even with broadly distributed vesicle:Ca2+-channel distances.
    1. Microbiology and Infectious Disease

    Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

    Michael B Schulte et al.
    A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky et al.
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng et al.
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves et al.
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.

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