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    1. Computational and Systems Biology

    Antibiotic-induced population fluctuations and stochastic clearance of bacteria

    Jessica Coates, Bo Ryoung Park ... Minsu Kim
    The extinction of bacterial populations by antibiotics is stochastic and can be predicted only probabilistically, not deterministically.
    1. Computational and Systems Biology

    Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions

    Xiaoming Fu, Heta P Patel ... Ramon Grima
    A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.
    1. Cell Biology

    Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

    Shankar Mukherji, Erin K O'Shea
    A systematic comparison of experimentally measured and theoretically predicted magnitudes of organelle abundance fluctuations suggests that budding yeast produces the maximum level of variability in organelle abundance that can be generated by organelle biogenesis pathways.
    1. Neuroscience

    Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

    Jun Kunimatsu, Tomoki W Suzuki ... Masaki Tanaka
    Neuronal activity in the striatum keeps track of elapsed time during the time production task while that in the cerebellum correlates with stochastic variation of self-timing in the range of several hundreds of milliseconds.
    1. Neuroscience
    2. Physics of Living Systems

    Elements of a stochastic 3D prediction engine in larval zebrafish prey capture

    Andrew D Bolton, Martin Haesemeyer ... Florian Engert
    Zebrafish implement a stochastic recursive algorithm during prey capture that reflects an implicit physical model of the world.
    1. Neuroscience

    The cellular architecture of memory modules in Drosophila supports stochastic input integration

    Omar A Hafez, Benjamin Escribano ... Jan Pielage
    Computational modeling of a central decision neuron of Drosophila reveals an electrotonically compact architecture that is ideally suited to support efficient memory storage within a stochastically connected memory circuit.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

    Sinan Uğur Umu, Anthony M Poole ... Paul P Gardner
    Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips, Cerys S Manning ... Nancy Papalopulu
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Microbiology and Infectious Disease

    Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

    Karthik Hullahalli, Matthew K Waldor
    During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone, Kirsty Hey ... Julian RE Davis
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.