Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
An analysis of within-host bacterial proliferation reveals that minor "stochastic" variation in the ability of the innate immune response to control bacterial growth early on can result in either survival or death of the host.
Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
Analysis of aging yeast cells using the in-vivo roGFP2-based probe reveals redox-dependent heterogeneity, reflected in a bi-modal distribution of the oxidation status, differential growth and replication, as well as distinct proteomic and transcriptomic profiles.