1,633 results found
  1. Episode 3: August 2013

    Episode 3: August 2013

    In this episode we hear about the cocktail party effect, the role of psuedogene RNA in the immune response, the genetic origins of a common form of blindness, the flu vaccine, and the origins of schistosomiasis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Structural Biology and Molecular Biophysics

    Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

    SeCheol Oh et al.
    Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of K+ ions.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Neuroscience

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

    Jason D Vevea, Edwin R Chapman
    Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
    1. Neuroscience

    Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

    Christina Chatzi et al.
    Single episodes of voluntary exercise induced a functional increase in hippocampal synapses mediated by activity-dependent expression of the BAR protein Mtss1L, acting as a novel early effector of synapse formation.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.
    1. Neuroscience

    A multicellular rosette-mediated collective dendrite extension

    Li Fan et al.
    Migrating skin carries the amphid rosette vertex anteriorly to extrude and position dendrites.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

    Mustafa Mir et al.
    The probability of transcription factors binding to their target sites is choreographed through the formation of dynamic multi-protein hubs that transiently interact with actively transcribing genes.

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