752 results found
    1. Neuroscience

    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

    Diptendu Mukherjee et al.
    The ventrolateral striatum is found to be recruited during the encoding of cocaine preference, within which Egr2-expressing ensembles are functionally important, as is the expression of Egr2 within them.
    1. Neuroscience

    Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning

    James Peak et al.
    Direct and indirect pathway neurons in posterior dorsomedial striatum were found to play distinct roles, with the former necessary for encoding and the latter for updating goal-directed learning.
    1. Neuroscience

    Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

    Mark Howe et al.
    Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.
    1. Neuroscience

    Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

    Youna Vandaele et al.
    Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Neuroscience

    Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

    Javier Alegre-Cortés et al.
    Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.
    1. Neuroscience

    Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Iku Tsutsui-Kimura et al.
    Dopamine signals in the ventral, dorsomedial, and dorsolateral striatum are modulated by various variables, such as stimulus-associated value, choice, confidence, but these modulations can be inclusively explained by TD errors.
    1. Neuroscience

    A comprehensive excitatory input map of the striatum reveals novel functional organization

    Barbara J Hunnicutt et al.
    The first comprehensive map of all excitatory inputs to the mouse striatum is presented and used to define and demarcate striatal subdivisions, including a previous unappreciated novel subdivision in the posterior striatum.
    1. Computational and Systems Biology
    2. Neuroscience

    A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning

    Nicholas T Franklin, Michael J Frank
    Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.
    1. Neuroscience

    Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice

    William Menegas et al.
    Dopamine novelty signals are localized in the posterior tail of the striatum along with general salience signals, while dopamine in the ventral striatum reliably encodes reward prediction error.

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