2,618 results found
    1. Microbiology and Infectious Disease

    NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli

    Loïc Léger et al.
    Genetic and biochemical approaches uncover a novel mode of regulation of the alarmone synthetase RelA through a functional and direct interaction with the small subunit of the nitrite reductase NirD.
    1. Structural Biology and Molecular Biophysics

    Ribosome•RelA structures reveal the mechanism of stringent response activation

    Anna B Loveland et al.
    Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.
    1. Microbiology and Infectious Disease

    Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

    Isao Masuda et al.
    Biochemical and genome-wide analysis demonstrates that m1G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2

    Elektra K Robinson et al.
    Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.
    1. Microbiology and Infectious Disease

    Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA

    Tera C Levin et al.
    Legionella pneumophila can be inhibited by its own antimicrobial, HGA (homogentisic acid), but its density-dependent resistance to HGA restricts the potential for self-harm.
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence et al.
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro et al.
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii

    Sarah L Sokol et al.
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A combination of transcription factors mediates inducible interchromosomal contacts

    Seungsoo Kim et al.
    A pooled mutational scanning approach for 3D chromosome conformation reveals how multiple transcription factors can jointly specify condition-specific genome conformations.

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