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    1. Cell Biology

    Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina M Calabrese ... Charles R Farber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    Simon Perrin, Maria Ethel ... Céline Colnot
    A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
    1. Developmental Biology

    The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    Pooja Popli, Arin K Oestreich ... Ramakrishna Kommagani
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

    Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cell Biology

    Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

    Ewa K Bomba-Warczak, Karen M Velez ... Francesca E Duncan
    Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

    Archana Kamalakar, Brendan Tobin ... Steven L Goudy
    Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
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