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Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.

Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.

The investigation of neuroimmunology in non-model organisms is critical to diversify the field and identify primordial principles that govern neuroimmune communication across taxa.

Genetic and biochemical analyses uncover a dichotomy of ERK pathway functions in osteoblasts, whereby ERK activation promotes the early differentiation of osteoblast precursors, but inhibits the subsequent differentiation of committed osteoblasts via mTOR-mediated regulation of mitochondrial function and SGK1.

Proline is essential for osteoblast differentiation and bone formation by facilitating the production of proline-enriched osteoblast proteins.

Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.

The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.

Long Pentaxin 3 is highly expressed by non-hematopoietic cells during Streptococcus pneumoniae invasive infections and regulates polymorphonuclear neutrophils' recruitment through interaction with P-selectin which damps inflammation-associated tissue damage and pneumococcal systemic dissemination.