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    1. Developmental Biology

    Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

    Pankaj Sahai-Hernandez, Claire Pouget ... David Traver
    A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

    Rafael Soares Godoy, Nicholas D Cober ... Duncan J Stewart
    Single-cell transcriptomic analysis reveals novel regenerative endothelial cell populations that mediate remarkably rapid and complete microvascular repair in a novel model of acute lung injury induced by endothelial cell ablation.
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco, Valérie Petit ... Marie-Ange Deugnier
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

    Yoko Ogawa, Satoru Morikawa ... Shigeto Shimmura
    PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu, Yiyun Wang ... Aaron Watkins James
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.
    1. Immunology and Inflammation

    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

    Ken-ichi Hirano, Hiroyuki Hosokawa ... Katsuto Hozumi
    LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.
    1. Stem Cells and Regenerative Medicine

    Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

    Bo Shen, Kristy Vardy ... Sean J Morrison
    Integrin a11 is identified as an Osteolectin receptor, revealing a new mechanism for adult skeletal bone maintenance in which Osteolectin/a11b1 signaling promotes bone formation by activating the Wnt pathway.
    1. Medicine

    Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

    Nicole Aaron, Michael J Kraakman ... Li Qiang
    Adipsin, the oldest known adipokine, has a novel role as a a regulator of bone marrow fat and, consequently, overall bone health.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nephron progenitor commitment is a stochastic process influenced by cell migration

    Kynan T Lawlor, Luke Zappia ... Alexander N Combes
    Stochastic cell migration modulates exposure to signals that regulate commitment in the nephron progenitor niche.
    1. Stem Cells and Regenerative Medicine

    Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

    In Young Choi, Hotae Lim ... Gabsang Lee
    Using multiple genetic reporter system in human pluripotent stem cells, a transcriptional database for human early myogenesis has been established.