4,774 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

    Xiaocheng Zhao et al.
    The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

    Roman Sloutsky, Kristen M Naegle
    Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
    1. Biochemistry and Chemical Biology

    Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

    Shannon N Mostyn et al.
    Identification of how bioactive lipids bind and inhibit glycine transporters has the potential to be exploited in the development of a new class of analgesics for chronic pain.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

    Andrey Poleshko et al.
    The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky et al.
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Rats exhibit similar biases in foraging and intertemporal choice tasks

    Gary A Kane et al.
    In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism of TRPV2 channel modulation by cannabidiol

    Ruth A Pumroy et al.
    Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.

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