1,225 results found
  1. September 2016

    Episode 32: September 2016

    In this episode we hear about ancient proteins, aging mice, mosquito nets, resourceful plants and cocktail party conversations.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Neuroscience

    Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

    Dario Maschi et al.
    Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper et al.
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

    Yu-Hsien Hwang Fu et al.
    Single molecule microscopy combined with biochemical analyses show that a two-step lipid-binding mechanism of the SRP receptor balances the trade-off between speed and specificity during co-translational protein targeting.
    1. Neuroscience
    2. Computational and Systems Biology

    Dynamic structure of locomotor behavior in walking fruit flies

    Alexander Y Katsov et al.
    A principled statistical segmentation of fruit fly walking leads to a compact model of immediate actions that can reproduce the unique behavioral sequences of individual flies.
    1. Cell Biology

    ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

    Lu Zhu et al.
    The lysosome membrane is a new functional location for the ESCRTs in yeast.
    1. Developmental Biology
    2. Neuroscience

    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

    Chien-Hsiang Wang et al.
    Maintenance of ubiquitin homeostasis is essential for proper control of the size of postsynaptic density and the growth of specialized membrane structure.
    1. Cell Biology
    2. Computational and Systems Biology

    Decoupling global biases and local interactions between cell biological variables

    Assaf Zaritsky et al.
    DeBias is a generic method to decompose and quantify the confounding, global factors and direct interactions of pairwise interacting variables.

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